Engineered Mannitol Ternary Additives Improve Dispersion of Lactose–Salbutamol Sulphate Dry Powder Inhalations
نویسندگان
چکیده
منابع مشابه
The Effect of Solvent Treatment on the Performance of Various Carriers in Dry Powder Inhalations Containing Salbutamol Sulphate
Objective(s): It has been suggested that the efficiency of dry poder inhaler (DPI) is generally low. Therefore, the aim of the present research work was to use the solvent treatment of the carrier in DPIformulations to see the possibility of inducing desirable characteristics. Materials and Methods: Lactose sieve fractions of 63-90 μm were submerged in ethanol or 80% v/v etha...
متن کاملThe Effect of Solvent Treatment on the Performance of Various Carriers in Dry Powder Inhalations Containing Salbutamol Sulphate
UNLABELLED Objective(s) : It has been suggested that the efficiency of dry poder inhaler (DPI) is generally low. Therefore, the aim of the present research work was to use the solvent treatment of the carrier in DPIformulations to see the possibility of inducing desirable characteristics. MATERIALS AND METHODS Lactose sieve fractions of 63-90 µm were submerged in ethanol or 80% v/v ethanol, m...
متن کاملInfluence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers
This study provides, for the first time, an evaluation of the physicochemical properties of batch cooling crystallized mannitol particles combined with how these properties correlated with the inhalation performance from a dry powder inhaler (Aerolizer). The results showed that the type of polymorph changed from β-form (commercial mannitol) to mixtures of β+ δ-mannitol (cooling crystallized man...
متن کاملInhalation of dry-powder mannitol increases mucociliary clearance.
Inhalation of hypertonic saline stimulates mucociliary clearance (MCC) in healthy subjects and those with obstructive lung disease. We investigated the effect of inhaling the osmotic agent mannitol on MCC. We used a dry-powder preparation of mannitol British Pharmacopea (BP) which was encapsulated and delivered using a Dinkihaler. MCC was measured for 75 min in six asthmatic and six healthy sub...
متن کاملthe effect of solvent treatment on the performance of various carriers in dry powder inhalations containing salbutamol sulphate
objective(s): it has been suggested that the efficiency of dry poder inhaler (dpi) is generally low. therefore, the aim of the present research work was to use the solvent treatment of the carrier in dpiformulations to see the possibility of inducing desirable characteristics. materials and methods: lactose sieve fractions of 63-90 μm were submerged in ethanol or 80% v/v ethanol, methanol or ...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2013
ISSN: 1550-7416
DOI: 10.1208/s12248-013-9476-4